Colorectal cancer is now the 3rd most common cancer in India and its incidence is rising in urban populations. It is highly curable when caught in stages I–III. Laparoscopic surgical expertise, total mesorectal excision for rectal cancer, and multidisciplinary care at Dhaara Liver Clinic, Yelahanka.
Colorectal cancer (CRC) is malignancy arising from the inner lining of the colon (large intestine) or rectum. 95% are adenocarcinomas — beginning as polyps that slowly transform into cancer over 5–15 years. This slow progression is what makes screening so effective: remove the polyp before it becomes cancer.
In India, CRC incidence has been rising steadily over two decades, driven by dietary changes (low fibre, high processed food), physical inactivity, obesity, alcohol consumption, and increasing life expectancy. Urban populations in Bangalore, Mumbai, and Delhi have the highest incidence.
T1–T2, N0, M0. Surgery alone — curative in 85–95% of patients. No chemotherapy needed.
T3–T4, N0, M0. Surgery ± adjuvant chemotherapy based on risk features. 5-year survival 70–80%.
Any T, N+, M0. Surgery + 6 months FOLFOX/CAPOX chemotherapy. 5-year survival 40–60%. Rectal cancer: neoadjuvant chemoRT first.
Liver, lung, or peritoneal metastases. Chemotherapy ± targeted therapy. Selected patients: resection of liver mets is curative. 5-year survival 10–20% (resected liver mets: 25–40%).
For cancers of the caecum, ascending colon, and hepatic flexure. Removes the right colon and its lymphovascular supply. Performed laparoscopically when possible. Bowel is reconnected — no permanent stoma needed.
For descending colon and sigmoid colon cancers. Standard complete mesocolic excision (CME) principles — removes entire embryological mesocolic envelope with its lymphatics for oncological completeness.
For mid and upper rectal cancers. Rectum is removed with total mesorectal excision (TME), bowel reconnected. A temporary covering loop ileostomy is usually created and reversed after 6–12 weeks. Sphincter and continence preserved.
For low rectal cancers involving the sphincter complex. Removes the rectum and anus through both abdominal and perineal incisions. Creates a permanent end colostomy. Required when sphincter preservation would compromise oncological clearance.
Temporary stomas created during cancer surgery are reversed once healing is confirmed — typically 6–12 weeks after the original operation. Reversal is planned, elective surgery with good outcomes when performed at the right time.
In selected patients with stage IV CRC and liver-only metastases: surgical resection of liver mets gives 25–40% 5-year survival — far better than chemotherapy alone. Requires HPB surgical expertise. Dr. Srinivas manages colorectal liver metastases as part of his HPB practice.
| Aspect | Laparoscopic | Open |
|---|---|---|
| Incisions | 3–5 small ports (5–12 mm) | Long midline incision |
| Hospital stay | 3–5 days | 5–8 days |
| Return to normal activity | 2–3 weeks | 4–6 weeks |
| Pain and analgesic need | Significantly less | More |
| Oncological outcomes | Equivalent — same lymph node harvest, same margins | Standard benchmark |
| Conversion to open | Required in 5–10% (advanced disease, obesity) | N/A |
| Blood loss | Less | More |
| Suitable for advanced/T4 tumours | Selective cases with expertise | Preferred |
Multiple RCTs (COST, CLASICC, COLOR) confirm laparoscopic CRC surgery achieves equivalent oncological results with significantly faster recovery. Dr. Srinivas performs laparoscopic colorectal surgery for suitable patients.
Lynch syndrome is caused by mutations in DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2). It accounts for 3–5% of all CRC. Features: CRC before age 50, multiple first-degree relatives with CRC or endometrial cancer, multiple CRCs. Lynch patients also have elevated risk of endometrial, ovarian, gastric, and urinary tract cancers.
FAP is caused by APC gene mutations and causes hundreds to thousands of colonic polyps from adolescence. Without intervention, CRC is virtually certain by age 40. Management:
The most important warning signs are: rectal bleeding or blood visible in the stool; a significant change in bowel habits persisting more than 4 weeks (new constipation, more frequent stools, alternating diarrhoea and constipation); a feeling of incomplete emptying after passing stool (tenesmus); unexplained iron deficiency anaemia (especially in men and post-menopausal women); significant unexplained weight loss; persistent lower abdominal cramping or bloating; and a palpable abdominal or rectal mass. The important thing to understand is that colorectal cancer in its early stages — when it is most curable — causes exactly these symptoms, which are also caused by many benign conditions. The error patients make is attributing these symptoms to piles, IBS, or stress without getting a colonoscopy.
Haemorrhoids (piles) are the most common cause of rectal bleeding in India, and the vast majority of patients with fresh rectal bleeding do have piles. However, colorectal cancer also causes rectal bleeding, and the two can coexist. The problem with attributing all rectal bleeding to piles is that cancer gets delayed by months or years. You need urgent colonoscopy if: you are above 45; the bleeding is mixed with the stool rather than only on tissue paper; you also have changed bowel habits or weight loss; you have iron deficiency anaemia; or the bleeding does not settle after treating piles. A colonoscopy is the only way to be certain. Never treat rectal bleeding with pile creams indefinitely without an endoscopic examination of the bowel.
In most cases, no — bowel is reconnected after the cancer is removed. For colon cancer: standard hemicolectomy removes the affected segment and rejoins the bowel — no stoma needed. For upper and mid rectal cancers: low anterior resection reconnects bowel; a temporary loop ileostomy is sometimes created for 6–12 weeks to allow healing, then reversed. For low rectal cancers very close to the anus: abdominoperineal resection (APR) removes the anal canal and sphincter muscles, requiring a permanent end colostomy. Whether you need a permanent stoma depends on how close your tumour is to the anus and your sphincter function. Discuss this specifically with your surgeon — advances in technique have allowed sphincter preservation in many low rectal cancers that previously required APR.
Total mesorectal excision (TME) is the surgical technique in which the rectum is removed together with its complete surrounding package of tissue — the mesorectum — within an intact fascial plane. This mesorectum contains the lymph nodes and small blood vessels where microscopic cancer spread occurs. Before TME became standard, local recurrence of rectal cancer was 20–40%. With TME, local recurrence is below 5% at specialist centres. It requires specific technical training, precise dissection in an avascular anatomical plane, and is strongly volume- and surgeon-dependent. The quality of TME — measured by the pathologist who examines the specimen — is one of the most important predictors of your long-term outcome. Ask your surgeon specifically about their experience with TME.
It depends on stage and location. For colon cancer: Stage I — surgery alone is curative. Stage II low-risk — surgery alone. Stage II high-risk (T4, perforation, obstruction, poor differentiation) — consider adjuvant CAPOX or FOLFOX chemotherapy. Stage III (lymph node positive) — adjuvant chemotherapy for 6 months is standard. For rectal cancer: locally advanced tumours (T3–T4 or node-positive on staging MRI) receive neoadjuvant long-course chemoradiotherapy (LCRT) or short-course radiotherapy before surgery — this shrinks the tumour, reduces local recurrence, and sometimes allows organ preservation. The treatment plan for every colorectal cancer patient should be discussed in a multidisciplinary team meeting involving surgery, oncology, radiology, and pathology.
For average-risk adults in India: start colonoscopy from age 45, every 10 years if normal (lower than the previous 50-year recommendation, driven by rising CRC in younger adults). Start earlier if: a parent or sibling was diagnosed with CRC or colorectal polyps — start at age 40 or 10 years before their age at diagnosis, whichever is earlier. If you have Lynch syndrome or FAP: start from age 25–30, annually. If you have ulcerative colitis or Crohn's colitis: surveillance colonoscopy from 8–10 years after diagnosis. Colonoscopy is uniquely powerful because it both finds and removes pre-cancerous polyps — turning a potential cancer into a preventable outcome.