MASLD · NAFLD · Metabolic Liver Disease

Fatty Liver Disease

Fatty liver (MASLD) is now the most common liver condition globally. Most people have no symptoms — but without monitoring, it can silently progress to cirrhosis and liver cancer.

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Understanding Fatty Liver Disease

Fatty liver disease (now called MASLD — Metabolic-Associated Steatotic Liver Disease) occurs when excess fat accumulates in liver cells. In India, 1 in 3 adults has fatty liver — most are unaware.

The Progression Spectrum

1
Simple Steatosis Fat in liver cells, no inflammation. Reversible.
2
MASH Steatohepatitis — fat + inflammation + injury
3
Fibrosis Scarring of liver tissue
4
Cirrhosis / HCC Advanced disease — transplant may be needed

Who Is at Risk?

  • Obesity or overweight (BMI > 25)
  • Type 2 diabetes or pre-diabetes
  • Metabolic syndrome (hypertension, dyslipidaemia, central obesity)
  • Hypothyroidism
  • Polycystic ovarian syndrome (PCOS)
  • Family history of liver disease
  • Sedentary lifestyle, high-carbohydrate diet
Important: You can have significant fatty liver with normal liver function tests (LFTs). Ultrasound and Fibroscan are more sensitive for early detection.

How Dr. Srinivas Assesses Fatty Liver

01

Clinical History & Blood Tests

LFTs, CBC, fasting lipid profile, HbA1c, thyroid function, and metabolic assessment to establish disease context.

02

Ultrasound Abdomen

Non-invasive imaging to confirm hepatic steatosis, assess liver size, and detect early fibrosis or portal hypertension signs.

03

Fibroscan (Liver Elastography)

Measures liver stiffness (fibrosis stage) and CAP score (fat content) without biopsy. Available at Dhaara Liver Clinic.

04

Liver Biopsy (when needed)

Gold standard for staging MASH and fibrosis when non-invasive tests are inconclusive or when diagnosis changes management.

Treatment & Management

Lifestyle Intervention

10% weight loss reduces liver fat by 50–80% and can reverse early MASH. Personalised diet and exercise programme with nutritionist collaboration.

Metabolic Control

Aggressive management of diabetes, hypertension, and dyslipidaemia. GLP-1 receptor agonists (semaglutide, liraglutide) are highly effective for MASLD with obesity.

Pharmacotherapy

Vitamin E (in non-diabetic MASH), pioglitazone (in diabetic MASH), and emerging approved agents (resmetirom/Rezdiffra) for fibrosis stage ≥ F2.

6-Monthly HCC Surveillance

Cirrhosis due to MASLD carries significant HCC risk. Regular ultrasound + AFP monitoring to detect liver cancer at an early, treatable stage.

Fatty Liver Detected on Ultrasound?

Don't ignore it. Send your ultrasound report and LFTs on WhatsApp for a rapid assessment of your fibrosis risk.

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